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Brain tumor - adultsDefinition A tumor is any growth of abnormal cells, or the uncontrolled growth of cells. This article is about primary brain tumors. These start in the brain, rather than spreading to the brain from another part of the body. See also:
Causes, incidence, and risk factors Primary brain tumors include any tumor that starts in the brain. Tumors may be confined to a small area, invasive (spread to nearby areas), benign (not cancerous), or malignant (cancerous). Tumors can directly destroy brain cells. They can also indirectly damage cells by producing inflammation, compressing other parts of the brain as the tumor grows, causing swelling in the brain, and increasing pressure within the skull. Brain tumors are classified depending on the exact site of the tumor, the type of tissue involved, benign or malignant tendencies of the tumor, and other factors. Primary brain tumors can arise from the brain cells, the meninges (membranes around the brain), nerves, or glands. The cause of primary brain tumors is unknown. This is because they are rare, there are many types, and there are many possible risk factors that could play a role. Exposure to some types of radiation, head injuries, and hormone replacement therapy may be risk factors, as well as many others. The risk of using cell phones is hotly debated. Some inherited conditions increase the risk of brain tumors, including neurofibromatosis, Von Hippel-Lindau syndrome, Li-Fraumeni syndrome, and Turcot's syndrome. Tumors may occur at any age, but many specific tumors have a particular age group in which they are most common. In adults, gliomas and meningiomas are most common. SPECIFIC TUMOR TYPES Gliomas are thought to be derived from glial cells such as astrocytes, oligodendrocytes, and ependymal cells. These tumors can have varying degrees of malignancy. The gliomas are subdivided into 3 types:
Treatment can involve surgery, radiation therapy, and chemotherapy, as well as experimental therapies in various combinations. Therefore, these tumors are best treated by a team involving a neurosurgeon, radiation oncologist, oncologist or neuro-oncologist, and others, such as neurologists and social workers. More recently, "molecular subtyping" of tumors is being used to make decisions about how to best treat a particular tumor. Because these tumors are difficult to cure, patients should consider enrolling in a clinical trial after talking with their treatment team. All of the above tumors can be difficult to remove completely by surgery alone, because the tumor invades surrounding brain tissue much like roots from a plant. It is often difficult for a neurosurgeon to determine where the tumor ends. Meningiomas are another type of brain tumor. These tumors:
Other primary brain tumors in adults are rare and can include ependymomas, craniopharyngiomas, pituitary tumors, pineal gland tumors, primary germ cell tumors of the brain, and other types. Symptoms The specific symptoms depend on the tumor's size, location, degree of invasion, and related swelling. Headaches, seizures, weakness in one part of the body, and changes in the person's mental functions are most common. Symptoms may include:
Signs and tests A doctor can often identify signs and symptoms that are specific to the location of the tumor. Some tumors may not show symptoms until they are very large and cause a rapid decline in the person's mental functions. Other tumors have symptoms that develop slowly. Most brain tumors increase pressure within the skull and compress brain tissue because of their size and weight. The following tests may confirm the presence of a brain tumor and identify its location:
Treatment A primary brain tumor should have prompt treatment. Early treatment improves the chance of a good outcome for many tumors. The treatment approach varies with the size and type of the tumor and the general health of the person. The goals of treatment may be to cure the disorder, relieve symptoms, and improve brain function or the person's comfort. Surgery is necessary for most primary brain tumors. Some may be completely removed. Tumors that are deep or that infiltrate brain tissue may be debulked (reducing the tumor's size and mass) rather than removed. In cases where the tumor cannot be removed, surgery may still help reduce pressure and relieve symptoms. Radiation therapy may be advised for tumors that are sensitive to radiation. Anticancer medications (chemotherapy) may be recommended. Other medications may include the following:
Comfort measures, safety measures, physical therapy, occupational therapy and other such steps may be required to improve quality of life. Counseling, support groups and similar measures may be needed to help in coping with the disorder. Legal advice may be helpful in creating advanced directives, such as power of attorney, in cases where the person's condition is expected to get worse. Support Groups For additional information, see cancer resources. Complications
Calling your health care provider Call your health care provider if you develop any new, persistent headaches or other symptoms suggestive of a brain tumor. Call your provider or go to the emergency room if you have seizures that are new, or suddenly develop stupor (reduced alertness), vision changes, or speech changes. Page Content: Glioblastoma multiforme - adults; Ependymoma - adults; Glioma - adults; Astrocytoma - adults; Medulloblastoma - adults; Neuroglioma - adults; Oligodendroglioma - adults; Meningioma - adults; Cancer - brain tumor (adults) ; adult brain glioma stem |
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