A weekly radio version of What's My Line? was produced from May 1952 until July 1953.

The same cast of regular panelists from the TV version (Dorothy Kilgallen, Bennett Cerf, Arlene Francis and Hal Block), along with host John Daly & announcer Lee Vines, premiered the radio version of their show on Tuesday May 20, 1952, while still performing the Sunday telecast.

The debut mystery guest, in her only appearance, was Marlene Dietrich. Marlon Brando made his only appearance on the radio program that aired on December 3, 1952.

The radio show continued through the "Hal Block era" into the "Steve Allen era" while once moving its broadcast to Wednesday.

The finale was broadcast on July 1, 1953.