| Player | Tyler Team(s) | Major League Team(s) |
| Wingo Anderson | 1912 Elbertas | 1910 Cincinnati Reds |
| Bill Andrus | 1926 Trojans | 1931 Washington Senators 1937 Philadelphia Phillies |
| Jim Avrea | 1947 Trojans | 1950 Cincinnati Reds |
| Heinz Becker | 1939 Trojans | 1943, 1945-46 Chicago Cubs 1946-47 Cleveland Indians |
| Fern Bell | 1934 Governors | 1939-40 Pittsburgh Pirates |
| Rabbit Benton | 1932 Sports | 1922 Philadelphia Phillies |
| Charlie Biggs | 1932 Sports | 1932 Chicago White Sox |
| George Binks | 1938 Trojans | 1944-46 Washington Senators 1947-48 Philadelphia Athletics 1948 St. Louis Browns |
| Bob Boken | 1929 Trojans | 1933-34 Washington Senators 1934 Chicago White Sox |
| Red Borom | 1940 Trojans | 1944-45 Detroit Tigers |
| Abe Bowman | 1924 Trojans | 1914 Cleveland Naps 1915 Cleveland Indians |
| Greg Brummett | 1996 WildCatters | 1993 Minnesota Twins 1993 San Francisco Giants |
| Hank Camelli | 1936 Trojans | 1943-46 Pittsburgh Pirates 1947 Boston Braves |
| Larry Carter | 1994 WildCatters | 1992 San Francisco Giants |
| Moose Clabaugh | 1926 Trojans | 1926 Brooklyn Robins |
| Merv Connors | 1951 East Texans | 1937-38 Chicago White Sox |
| Sam Covington | 1912 Elbertas | 1913 St. Louis Browns 1917-18 Boston Braves |
| Charlie Cuellar | 1938 Trojans | 1950 Chicago White Sox |
| Ray Cunningham | 1932 Sports | 1931-32 St. Louis Cardinals |
| Wally Dashiell | 1935-37 Trojans* | 1924 Chicago White Sox |
| Red Dorman | 1926, 1928 Trojans | 1928 Cleveland Indians |
| Hal Epps | 1951-52 East Texans | 1938, 1940 St. Louis Cardinals 1943-44 St. Louis Browns 1944 Philadelphia Athletics |
| Uel Eubanks | 1928-29 Trojans | 1922 Chicago Cubs |
| Darrell Evans | 1997 WildCatters** | 1969-76, 1989 Atlanta Braves 1976-83 San Francisco Giants 1984-88 Detroit Tigers |
| Kerby Farrell | 1934 Governors | 1943 Boston Braves 1945 Chicago White Sox |
| Bubba Floyd | 1938 Trojans | 1944 Detroit Tigers |
| Charlie Gassaway | 1937 Trojans | 1944 Chicago Cubs 1945 Philadelphia Athletics 1946 Cleveland Indians |
| Stan Goletz | 1950 Trojans | 1941 Chicago White Sox |
| George Harper | 1932 Sports | 1916-18 Detroit Tigers 1922-24 Cincinnati Reds 1924-26 Philadelphia Phillies 1927-28 New York Giants 1928 St. Louis Cardinals 1929 Boston Braves |
| Dave Hilton | 1996 WildCatters** | 1972-1975 San Diego Padres |
| Jessie Hollins | 1997 WildCatters | 1992 Chicago Cubs |
| George Jackson | 1924-25, 1927-28 Trojans* | 1911-13 Boston Braves |
| Johnny Jones | 1928 Trojans | 1919 New York Giants 1920 Boston Braves |
| Jim Kirby | 1946 Trojans 1953 East Texans |
1949 Chicago Cubs |
| Jack Knight | 1931 Trojans | 1922 St. Louis Cardinals 1925-26 Philadelphia Phillies 1927 Boston Braves |
| Joe Kracher | 1950 Trojans* 1951 East Texans |
1939 Philadelphia Phillies |
| Wayne Krenchicki | 1995 WildCatters** | 1979-81 Baltimore Orioles 1982, 1983-1985 Cincinnati Reds 1983 Detroit Tigers 1986 Montreal Expos |
| Jesse Landrum | 1949 Trojans | 1938 Chicago White Sox |
| Roy Leslie | 1929 Trojans** | 1917 Chicago Cubs 1919 St. Louis Cardinals 1922 Philadelphia Phillies |
| Lou Lombardo | 1954 Tigers | 1948 New York Giants |
| Babe Martin | 1940 Trojans | 1944-46, 1953 St. Louis Browns 1948-49 Boston Red Sox |
| Tex McDonald | 1926 Trojans | 1912-13 Cincinnati Reds 1913 Boston Braves 1914 Pittsburgh Stogies (Federal League) 1914 Buffalo BufFeds (Federal League) 1915 Buffalo Blues (Federal League) |
| Bill McGhee | 1932 Sports | 1944-45 Philadelphia Athletics |
| Jim McLaughlin | 1932 Tyler Sports | 1932 St. Louis Browns |
| Pat McLaughlin | 1951 East Texans | 1937, 1945 Detroit Tigers 1940 Philadelphia Athletics |
| Roy McMillan | 1947-48 Trojans | 1951-60 Cincinnati Reds 1961-64 Milwaukee Braves 1964-66 New York Mets Manager: 1972 Milwaukee Brewers 1975 New York Mets |
| Carl McNabb | 1936-38 Trojans 1947-49 Trojans* |
1945 Detroit Tigers |
| Rufus Meadows | 1935, 1937 Trojans | 1926 Cincinnati Reds |
| Horace Milan | 1912 Elbertas | 1915, 1917 Washington Senators |
| Hack Miller | 1947-48 Trojans | 1944-45 Detroit Tigers |
| J. Walter Morris | 1932 Sports** | 1908 St. Louis Cardinals |
| Wally Moses | 1932 Sports | 1935-41, 1949-51 Philadelphia Athletics 1942-46 Chicago White Sox 1946-48 Boston Red Sox |
| Red Murff | 1952 East Texans | 1956-57 Milwaukee Braves |
| Alex Mustaikis | 1933 Governors | 1940 Boston Red Sox |
| Fred Nicholson | 1932 Sports | 1917 Detroit Tigers 1919-20 Pittsburgh Pirates 1921-22 Boston Braves |
| Otho Nitcholas | 1932 Sports 1948, 1950 Trojans* |
1945 Brooklyn Dodgers |
| Mickey O'Neil | 1932 Sports | 1919-25 Boston Braves 1927 Washington Senators 1927 New York Giants |
| Antonio Ordenana | 1951 East Texans | 1943 Pittsburgh Pirates |
| Salty Parker | 1954 Tigers** | 1936 Detroit Tigers Manager: 1967 New York Mets 1972 Houston Astros |
| Ken Patterson | 1996 WildCatters | 1988-91 Chicago White Sox 1992 Chicago Cubs 1993-94 California Angels |
| Leon Pettit | 1929 Trojans | 1935 Washington Senators 1937 Philadelphia Phillies |
| Todd Rizzo | 1994 WildCatters | 1998-99 Chicago White Sox |
| Bill Reeder | 1951 East Texans | 1949 St. Louis Cardinals |
| Red Rollings | 1938 Trojans | 1927-28 Boston Red Sox 1930 Boston Braves |
| Joe Rossi | 1946 Trojans | 1952 Cincinnati Reds |
| Wally Schang | 1932 Sports | 1913-17, 1930 Philadelphia Athletics 1918-20 Boston Red Sox 1921-25 New York Yankees 1926-29 St. Louis Cardinals 1931 Detroit Tigers |
| Marshall Scott | 1940 Trojans | 1945 Philadelphia Phillies |
| Tex Shirley | 1939 Trojans | 1941-42 Philadelphia Athletics 1944-46 St. Louis Browns |
| George Sisler | 1932 Sports* | 1915-27 St. Louis Browns 1928 Washington Senators 1928-30 Boston Braves |
| Jack Stansbury | 1926 Trojans | 1918 Boston Red Sox |
| Milt Steengrafe | 1932 Sports | 1923-24, 1926 Chicago White Sox |
| Bill Stein | 1994 WildCatters** | 1972-73 St. Louis Cardinals 1974-76 Chicago White Sox 1977-80 Seattle Mariners 1981-85 Texas Rangers |
| Stuffy Stewart | 1932 Sports | 1916-17 St. Louis Cardinals 1922 Pittsburgh Pirates 1923 Brooklyn Robins 1925-27, 1929 Washington Senators |
| Doug Taitt | 1938 Trojans* 1946 Trojans* |
1928-29 Red Sox 1929 White Sox 1931-32 Philadelphia Phillies |
| Jug Thesenga | 1940 Trojans | 1944 Washington Senators |
| Forrest Thompson | 1939 Trojans | 1948-49 Washington Senators |
| Cotton Tierney | 1912 Elbertas | 1920-23 Pittsburgh Pirates 1923 Philadelphia Phillies 1924 Boston Braves 1925 Brooklyn Robins |
| Jack Tising | 1924-25 Trojans | 1936 Pittsburgh Pirates |
| Joe Trimble | 1949 Trojans | 1955 Boston Red Sox 1957 Pittsburgh Pirates |
| Oscar Tuero | 1932 Sports 1934 Governors |
1918-20 St. Louis Cardinals |
| Willie Underhill | 1927 Trojans | 1927-28 Cleveland Indians |
| Harry Walker | 1938 Trojans | 1940-43, 1946-47, 1950-51, 1955 St. Louis Cardinals 1947-48 Philadelphia Phillies 1949 Chicago Cubs 1949 Cincinnati Reds Manager: 1955 St. Louis Cardinals 1965-67 Pittsburgh Pirates 1968-72 Houston Astros |
| Aaron Ward | 1932 Sports | 1917-26 New York Yankees 1927 Chicago White Sox 1928 Cleveland Indians |
| Jeff Ware | 2001 Roughnecks | 1995-96 Toronto Blue Jays |
| George Washington | 1932 Sports | 1935-36 Chicago White Sox |
| John Whitehead | 1929 Trojans | 1935-39 Chicago White Sox 1939-40, 1942 St. Louis Browns |
| Les Willis | 1932 Sports | 1947 Cleveland Indians |
| Hank Wyse | 1953 East Texans | 1942-47 Chicago Cubs 1950-51 Philadelphia Athletics 1951 Washington Senators |
| Carl Yowell | 1924 Trojans | 1924-25 Cleveland Indians |
| Roy Zimmerman | 1940 Trojans | 1945 New York Giants |
*player/manager **manager
Bill Tosheff, 1951-52 NBA co-Rookie of The Year (w/Mel Hutchins), posted an 8-6 record with the 1954 Tyler Tigers.