Genetic
Reprogramming Events in Cloned Animals
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Numerous
cloned mice, cows, goats and pigs have been born since Scottish scientists
cloned the first sheep, Dolly, in 1997. Yet it takes dozens or sometimes
hundreds of attempts to succeed.
Only
few clones are long-term survivors as 80 percent die during pregnancy or soon
after birth from defects suggesting that during embryonic and fetal
development the genes did not work properly.
Genetic
reprogramming events play important roles in survivability of clones. These
events include:
1)
X
chromosome inactivation reprogramming
2) Telomere length reprogramming3) Many more (imprinting genes, histones, ect. ) |
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