Genetic Reprogramming Events in Cloned Animals


Dr. Xiangzhong (Jerry ) Yang

Numerous cloned mice, cows, goats and pigs have been born since Scottish scientists cloned the first sheep, Dolly, in 1997. Yet it takes dozens or sometimes hundreds of attempts to succeed.
Only few clones are long-term survivors as 80 percent die during pregnancy or soon after birth from defects suggesting that during embryonic and fetal development the genes did not work properly.
Genetic reprogramming events play important roles in survivability of clones. These events include:
1)       X chromosome inactivation reprogramming
2)       Telomere length reprogramming
3)       Many more (imprinting genes, histones, ect. )
  1. Backgroud Information (Telomeres)
  2. Related Cloning and Telomere Stories
  3. Photos
  4. Pathological Status of Cloned Calves Born Pre-term
  5. Pathological Images of Cloned Calves Born Pre-term
  1. Aberrant patterns of X chromosome inactivation in bovine clones NEW
  2. Nature Genetics Paper (X chromosome inactivation) NEW
  3. Clones from aged cows have normal pregnancies and calving
  4. Bovine Telomere Length Reprogrammed
  5. Nature Genetics Paper (Telomere length reprogramming)
  6. PNAS Paper and Commentary (Long term culture cell cloning)
  7. Amy, 1st cloned cow in the U.S.
  8. First cloned male animals in the world
  9. Yang lab publications
  10. Yang lab publicity
  11. ANCS229-Animal Embryology and Biotechnology

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