Peter Parker is your basic average guy. He struggles to make ends meet, has trouble getting dates, and spents a lot of time looking after his family when they need help. He's also a webslinging superhero named Spider-Man, who gained Spider-like abilities after being bitten by a radioactive Spider. After using his new gifts for fame and fortune, the newfound adulation went to Pete's head, and he let a Burglar rob the studio he was working at. That Burglar would later try to rob Peter's Aunt May and Uncle Ben, resulting in a struggle that ended with the Burglar shooting Uncle Ben. Realising that he was responsible his Uncle's demise, Peter decided to become a hero, fully understanding what his Uncle Ben once told him. "With great power, comes great responsibility."

Peter eventually became well known around New York as both a hero and a menace, thanks to the editorials of J. Jonah Jameson, the editor turned publisher of the Daily Bugle, a tabloid that Peter sells photos of Spider-Man to. Peter continued being Spider-Man into college, where he met Gwen Stacy, his first true love, Harry Osborn, his best friend, and Mary Jane Watson, the niece of his Aunt's best friend. Eventually Peter was about to propose to Gwen, until her father was murdered and she left New York. She returned a short while later, but died during a fight between Peter and Harry's father Norman, the Green Goblin. The Goblin also appeared to parish during this fight.

Peter grew closer to Mary Jane, and also formed a friendship with Flash Thompson, who had previously bullied Peter in high school. Flash was the best man at Peter's wedding to Mary Jane. Harry married Liz Allen, Flash's ex, though he took on his father's mantle of the Goblin, and died a while later. A year after Harry's death, Norman returned, revealing that he had survived his "death" years before, thanks to his Goblin serum, and he kidnapped Peter and Mary Jane's newborn baby.

Currently Peter and Mary Jane are repairing their fractured relationship, while Norman continues to haunt Peter. Peter also his hands full since Aunt May discovered that he is Spider-Man.