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Idiopathic thrombocytopenic purpura (ITP)Definition Idiopathic thrombocytopenic purpura is a bleeding disorder characterized by too few platelets in the blood. This is because platelets are being destroyed by the immune system. Idiopathic means the exact cause of the disease is unknown. Because more is being learned about the autoimmune nature of the disease, it is sometimes called immune thrombocytopenic purpura. Causes, incidence, and risk factors The disease occurs when immune system cells, called lymphocytes, produce antibodies against platelets. Platelets are necessary for normal blood clotting. They clump together to plug small holes in damaged vessels. The presence of antibodies on platelets leads to their destruction in the spleen. A characteristic skin rash, easy bruising, abnormal menstrual bleeding, or sudden and severe loss of blood from the gastrointestinal tract may occur. Usually, no other abnormal findings are present. In children, the disease is sometimes preceded by a viral infection and usually runs its course without treatment. In adults, it is more often a chronic (long-term) disease and can follow a viral infection, certain drugs, pregnancy, or other immune disorders. ITP affects women more frequently than men, and is more common in children than adults. Equal numbers of boys and girls are affected. Symptoms
Signs and tests Tests include:
Treatment In children, the disease often runs its course without treatment. In adults, the initial treatment is usually with a drug called prednisone. A splenectomy (removal of the spleen) is sometimes advised. The spleen is the major site of platelet destruction, but removal of the spleen will only bring up the platelet count in 50% of people. Other treatments (when the disease does not respond to initial treatment) are:
People with ITP should avoid taking aspirin, ibuprofen, and warfarin because these drugs interfere with platelet function and blood clotting, and bleeding may occur. Expectations (prognosis) The chance of remission (a symptom-free period) is good with prednisone or a splenectomy. Rarely, ITP may become a chronic ailment in adults and reappear, even after remission. Complications
Calling your health care provider Go to the emergency room or call the local emergency number (such as 911) if severe bleeding occurs or other new symptoms develop. Prevention The causes and risk factors are unknown (except in children when it may be related to a viral infection), and prevention is unknown. Illustrations
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