Mingchao Shen, Ph.D.
Bioengineering, 2001, University of Washington, Seattle, WA USA.

Medical Devices / Biomaterials

Publications:

Shen M, Garcia I, Maier RV, Horbett TA. The effects of adsorbed proteins and surface chemistry on foreign body giant cell formation, TNFa release and procoagulant activity of monocytes. J Biomed Mater Res. 2004; 70A: 533–541. Abstract

Shen M, Wagner MS, Castner DG, Ratner BD, Horbett TA. Multivariate Surface Analysis of Plasma-Deposited Tetraglyme for Reduction of Protein Adsorption and Monocyte Adhesion. Langmuir. 2003; 19(5):1692-1699. Abstract

Wagner MS, Shen M, Horbett TA, Castner DG. Quantitative analysis of binary adsorbed protein films by time of flight secondary ion mass spectrometry. J Biomed Mater Res. 2003 Jan 1;64A(1):1-11. Abstract

Wagner MS, Shen M, Horbett TA, Castner DG. Quantitative time-of-flight secondary ion mass spectrometry for the characterization of multicomponent adsorbed protein films. Applied Surface Science, 203: 704-709, 2003. Abstract

Shen M, Martinson L, Wagner MS, Castner DG, Ratner BD, Horbett TA. PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies. J Biomater Sci Polym Ed. 2002;13(4):367-90. Abstract

Wagner MS, McArthur SL, Shen M, Horbett TA, Castner DG. Limits of detection for time of flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS): detection of low amounts of adsorbed protein. J Biomater Sci Polym Ed. 2002;13(4):407-28. Abstract

Shen M, Pan YV, Wagner MS, Hauch KD, Castner DG, Ratner BD, Horbett TA. Inhibition of monocyte adhesion and fibrinogen adsorption on glow discharge plasma deposited tetraethylene glycol dimethyl ether. J Biomater Sci Polym Ed. 2001;12(9):961-78. Abstract

Shen M, Horbett TA. The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. J Biomed Mater Res. 2001 Dec 5;57(3):336-45. Abstract

Hendricks SK, Kwok C, Shen M, Horbett TA, Ratner BD, Bryers JD. Plasma-deposited membranes for controlled release of antibiotic to prevent bacterial adhesion and biofilm formation. J Biomed Mater Res. 2000 May;50(2):160-70. Abstract

Presentations:

M Shen, MS Wagner, DG Castner, BD Ratner, TA Horbett. Invited talk. PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies. 2002 UWEB Summer Scientific Symposium on Non-Fouling Surfaces, Seattle, WA, 2002.

Microfluidics / Lab-on-a-chip

Presentations:

M Shen and KL Hedine. Integrated microfluidic cards and instrumentation for complex sample preparation and analysis, HTP screening, and medical diagnostics. Seventeenth International Forum Process Analytical Chemistry, Scottsdale, AZ, 2003.

M Shen and BH Weigl. Microfluidic devices for complex samples - the application of H-Filter and T-Sensor technology to cell analysis, HTP screening, and medical diagnostics. SmallTalk 2002. San Diego, CA, 2002.

M Shen and F Battrell. Fabrication of microfluidic sample preparation and chemical separation biochips. BIOMEMS 2002 4th Annual Meeting: Advances in medical and analytical applications. Cambridge, MA, 2002.

Biochemistry

A.J. Wolfson, T.R. Branham, J.C. Edgoose, A.K. Hammill, K.M. Lowe, A.E. Spooner, J. Lee, R. Kapoor and M. Shen. Kinetics of Inhibition of Elastase by a Chimeric Inhibitor Containing the Reactive Site Loop from alpha-Antitrypsin. Protein and Peptide Letter, 3 (5), 293-300, 1996.


Personal activities