Sports steroids
Long gone are the days of simple trial and error when it comes to building muscle. sports steroids Steroid effects. The modern bodybuilder demands more than just "hear say" if they are to adopt a new training routine or nutritional supplement. This column was created to keep today's bodybuilder on the cutting edge of scientific research that might benefit them in their quest for body perfection. Title:Discovery of nonsteroidal androgens. sports steroids Anabolic steriods. Researchers:Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DDDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, MemphisSource:Biochem Biophys Res Commun. 244(1):1-4, 1998Summary:An in vitro study was performed to assess the ability of non-steroidal compounds to bind with the androgen receptor (AR) and activate transcription. The compounds to be tested were derived from the structure of the anti-androgen R-Bicalutamide. sports steroids Male-muscle-pictures. The androgen receptors were prepared using the prostate glands of male Sprague-Dawley rats. Transcriptional activation was measured using transfected CV-1 cells. In order to assess the binding affinity of these compounds, they were incubated in a medium containing androgen receptors. Each compound was tested in increasing concentrations until the minimum concentration that resulted in maximum receptor saturation was attained. Then the experiment was repeated using the high affinity ligand, 3H-MIB. The concentration of each compound needed to completely saturate the androgen receptors was then compared to the amount of 3H-MIB needed to do the same. The efficacy (i. e. maximal degree of AR-mediated transcriptional activity observed) and potency (i. e. the lowest concentration of ligand able to induce maximal transcriptional activity) were determined by comparing the transcriptional activity induced by various concentrations of each compound to that of dihydrotestosterone (DHT). The efficacy of individual compounds compared to DHT was calculated by dividing the maximal transcriptional activation observed for each compound by the maximal transcriptional activation observed for DHT. All experiments were performed in triplicate. Potency was reported as the lowest concentration of the ligand used during transfection experiments capable of producing maximal androgen receptor-mediated transcriptional activity. Discussion:First a few words about the study design.
Sports steroids
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