Caine is a supervisor at the Miami-Dade crime lab, a forensic analyst and former homicide detective and bomb squad officer. He is very protective of his team, who affectionately call him "H." He is very concerned about the reputation of his lab, and takes great care to keep them clean, perhaps because of his experience with his tarnished younger brother, Ray.
He is a commissioned police officer, and thus carries a badge and gun. He is very insistent on gun maintenance, especially since team member Tim Speedle was killed in a shootout after his gun misfired.
Caine's parents named him after author Horatio Alger. Before he moved to Miami, Caine worked in New York City. It was there that he killed the man who murdered his mother his own father. After his arrival in Florida, Horatio joined the Miami-Dade Police as a homicide detective but later transferred to the bomb squad, where he was mentored by Al Humphries, an older cop. Finally, Caine moves to the Crime Lab, accepting a promotion to lieutenant. When veteran CSI Megan Donner goes on personal leave following the death of her husband, Horatio becomes the permanent head of the lab.
He has many recurring enemies throughout the series. Some he thought put away for good come back to haunt him.
